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Updated: Jun 11, 2026
08:01
Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Eliciting the T cell fate with Notch
Dil Afroz Sultana1, J Jeremiah Bell, Daniel A Zlotoff
1Department of Pathology and Laboratory Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Seminars in Immunology
|July 15, 2010
Summary
The thymus directs blood-borne progenitors to become T cells, with Notch signaling initiating this crucial developmental pathway. Understanding this process could aid in generating T cells for therapeutic applications.
Area of Science:
- Immunology
- Developmental Biology
- Cell Biology
Background:
- The thymus is essential for T cell development from blood-borne progenitors.
- T cell lineage commitment requires precise regulation of progenitor cell fates.
- Notch signaling is implicated as an initial trigger in T cell development.
Purpose of the Study:
- To investigate the role of Notch signaling in T cell lineage commitment.
- To understand how thymic signals guide progenitor differentiation.
- To explore potential translational applications for T cell generation.
Main Methods:
- Analysis of progenitor cell differentiation within the thymus.
- Investigating Notch pathway activation and downstream targets.
- Studying the influence of thymic microenvironment signals.
Main Results:
- Notch signaling initiates the T cell developmental program.
- Specific downstream targets of Notch are involved in lineage commitment.
- Thymic signals are critical for constraining non-T cell fates.
Conclusions:
- Notch signaling is a key initiator of T cell fate determination in the thymus.
- Further research into Notch targets can elucidate T cell development.
- This knowledge may enable in vitro T cell generation for therapeutic purposes.
Related Concept Videos
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Naive T cells that have not yet encountered an antigen express two primary CD...
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01:16TGF - β Signaling Pathway
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