Related Experiment Video
Updated: Jun 11, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Positive neonatal screening for cystic fibrosis in neonates with renal failure
Michiel J S Oosterveld1, Jaap V Schilperoort, Marc R Lilien
1Department of Paediatric Nephrology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, KE 04.113.1, Utrecht 3508 AB, The Netherlands. m.j.s.oosterveld@umcutrecht.nl
Abstract:
Screening for cystic fibrosis (CF) was recently added to the neonatal screening programme in the Netherlands. Four patients with renal failure whose heel prick tests were positive for CF as defined by raised levels of immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) are described. Both cystic fibrosis transmembrane conductance regulator (CFTR) DNA analysis and sweat tests were negative. Limited renal function can be a cause of false positive neonatal screening for CF using IRT and PAP.
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