Nomenclature of monocytes and dendritic cells in blood

Area of Science:

• Immunology
• Cell Biology

Background:

• Monocytes and dendritic cells are crucial immune cells circulating in blood and migrating to tissues.
• Detailed characterization using cell surface markers and flow cytometry has revealed diverse subpopulations.
• Existing classifications lack standardization, hindering clear communication within the scientific community.

Purpose of the Study:

• To propose and define a standardized nomenclature for monocyte and dendritic cell subpopulations in human and mouse blood.
• To facilitate clearer communication and understanding among immunologists and researchers.
• To establish a consensus classification for key immune cell types.

Main Methods:

• Review and synthesis of existing literature on monocyte and dendritic cell characterization.
• Application of cell surface marker analysis and flow cytometry data.
• Formal proposal and approval by the Nomenclature Committee of the International Union of Immunological Societies.

Main Results:

• Definition of three distinct monocyte subpopulations: classical, intermediate, and nonclassical monocytes.
• Definition of three distinct dendritic cell subpopulations: plasmacytoid dendritic cells and two types of myeloid dendritic cells.
• Classification established for both human and mouse blood.

Conclusions:

• The proposed nomenclature provides a clear and unified framework for classifying monocytes and dendritic cells.
• This standardized classification is expected to enhance research reproducibility and collaborative efforts.
• The nomenclature has been officially approved, ensuring its widespread adoption and utility.