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Association between tryptophan hydroxylase 2 polymorphism and anger-related personality traits among young Korean
Jaewon Yang1, Moon-Soo Lee, So-Hee Lee
1Department of Psychiatry, Korea University, Seoul, South Korea.
Background/Aims:
It has been suggested that the serotonergic systems are associated with anger and aggressive behaviors. We investigated the association between several single nucleotide polymorphisms in the serotonergic genes and anger-related personality traits.
Methods:
A total of 228 healthy female Korean women participated in this study. All subjects were assessed with the State-Trait Anger Expression Inventory (STAXI) and were genotyped for 3 polymorphisms: serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR), tryptophan hydroxylase 1 (TPH1) A218C, and TPH2 G-703T.
Results:
The Anger Expression-Out (AX-Out) subscale scores of the STAXI differed significantly between the genotypes for the TPH2 G-703T polymorphism (F = 4.825, p = 0.009). G/G homozygous subjects scored significantly higher on the AX-Out subscale than those with the G/T genotype. However, no significant differences were observed in the relationships between the STAXI subscale scores of subjects with other polymorphisms.
Conclusions:
This study suggests that the TPH2 G-703T polymorphism might contribute to anger-related traits, especially to the expression of anger.
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