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Updated: Jun 11, 2026

Implementing Dynamic Clamp with Synaptic and Artificial Conductances in Mouse Retinal Ganglion Cells
Published on: May 16, 2013
Influence of GABAergic inhibition on concerted activity between the ganglion cells
Wei Jing1, Wen-Zhong Liu, Xin-Wei Gong
1Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Abstract:
In this study, the spike discharges of one subtype of bullfrog retinal ganglion cells (dimming detectors) in response to repetitive full field light-OFF stimuli were recorded using multi-electrode arrays. Two different types of concerted activity (precise synchronization and correlated activity) could be distinguished. The nearby cells with overlapped receptive field areas often fired in synchrony, whereas the correlated activity was mainly observed from remote cell pairs with separated receptive fields. After the bicuculline application, the strength of the synchronized activity was increased whereas that of the correlated activity was decreased. These results suggest that the activation of GABAA-receptor-mediated inhibitory pathways differentially modulates the concerted firing of the ganglion cells.
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