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Updated: Jun 11, 2026
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
The impact of lymph node density on survival of cervical cancer patients
S Polterauer1, L Hefler, V Seebacher
1Department of Gynecology and Gynecologic Oncology, Medical University of Vienna, Waehringer Guertel 18-20,Vienna A-1090, Austria. stephan.polterauer@meduniwien.ac.at
Background:
To evaluate the prognostic value of lymph node density (LND) in patients with lymph node-positive cervical cancer.
Methods:
A total of 88 consecutive patients were included in our study. Patients were treated with cisplatin-based concomitant chemoradiotherapy after surgical staging was performed at the Medical University of Vienna. Lymph node density, that is, the ratio of positive lymph nodes to the total number of lymph nodes removed, was assessed pathologically. Patients were stratified into two groups according to LND: patients with LND
Results:
A significant correlation between LND and FIGO stage (P=0.03), but not patients' age (P=0.2), histological grade (P=0.8), and histological type (P=0.5), was observed. In a univariate survival analysis, LND (P=0.01; P=0.01), FIGO stage (P=0.01; P=0.008), and histological grade (P=0.03; P=0.04) were associated with disease-free and overall survival, respectively. Patients with LND >10% had impaired disease-free and overall survival rates compared with patients with LND
Conclusions:
LND >10% is associated with an impaired disease-free and overall survival. Lymph node density may be used as an independent prognostic parameter in patients with lymph node-positive cervical cancer.
