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Targeted Cancer Therapies

Targeted Cancer Therapies

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There are several types of targeted therapies against specific...

Targeted Cancer Therapies

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Related Experiment Video

Updated: Jun 11, 2026

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Published on: May 1, 2015

Integrin alpha(v)beta(3)-Targeted Cancer Therapy.

Zhaofei Liu¹, Fan Wang, Xiaoyuan Chen

¹Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Biophysics, and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305.

Drug Development Research

|July 15, 2010

Summary

This summary is machine-generated.

Targeting integrin alpha(v)beta(3) offers a promising anti-angiogenesis strategy for cancer treatment. Blocking this integrin shows potential in inhibiting tumor growth, angiogenesis, and metastasis.

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A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies

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Published on: August 8, 2019

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Integrins are crucial molecular players in tumor angiogenesis.
Integrin alpha(v)beta(3) is particularly significant in this process.
Blocking integrin signaling can inhibit tumor growth, angiogenesis, and metastasis.

Purpose of the Study:

To review the role of integrin alpha(v)beta(3) in angiogenesis.
To present recent advancements in using integrin alpha(v)beta(3) antagonists for cancer therapy.
To discuss integrin-targeted delivery systems and future perspectives in cancer therapeutics.

Main Methods:

Review of scientific literature on integrin alpha(v)beta(3) and angiogenesis.
Analysis of studies involving integrin alpha(v)beta(3) antagonists (antibodies, peptides, peptidomimetics).
Examination of integrin-targeted delivery systems for cancer therapeutics.

Main Results:

Integrin alpha(v)beta(3) is highly expressed on activated endothelial cells and tumor neovasculature.
Inhibition of integrin alpha(v)beta(3) signaling demonstrates efficacy in preclinical models.
Integrin alpha(v)beta(3) antagonists show potential as targeted anti-cancer agents.

Conclusions:

Integrin alpha(v)beta(3) is a validated target for anti-angiogenic cancer therapy.
Various antagonists and targeted delivery systems are being developed for clinical application.
Further research into integrin alpha(v)beta(3) blockade holds promise for improved cancer treatment outcomes.