Related Experiment Video

Updated: Jun 11, 2026

Three-Dimensional (3D) Tumor Spheroid Invasion Assay
12:19

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

Published on: May 1, 2015

Integrin alpha(v)beta(3)-Targeted Cancer Therapy

Zhaofei Liu1, Fan Wang, Xiaoyuan Chen

  • 1Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Biophysics, and Bio-X Program, Stanford University School of Medicine, Stanford, CA 94305.

Drug Development Research
|July 15, 2010
PubMed

Insights

Targeting integrin alpha(v)beta(3) offers a promising anti-angiogenesis strategy for cancer treatment. Blocking this integrin shows potential in inhibiting tumor growth, angiogenesis, and metastasis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Integrins are crucial molecular players in tumor angiogenesis.
  • Integrin alpha(v)beta(3) is particularly significant in this process.
  • Blocking integrin signaling can inhibit tumor growth, angiogenesis, and metastasis.

Purpose of the Study:

  • To review the role of integrin alpha(v)beta(3) in angiogenesis.
  • To present recent advancements in using integrin alpha(v)beta(3) antagonists for cancer therapy.
  • To discuss integrin-targeted delivery systems and future perspectives in cancer therapeutics.

Main Methods:

  • Review of scientific literature on integrin alpha(v)beta(3) and angiogenesis.
  • Analysis of studies involving integrin alpha(v)beta(3) antagonists (antibodies, peptides, peptidomimetics).
  • Examination of integrin-targeted delivery systems for cancer therapeutics.

Main Results:

  • Integrin alpha(v)beta(3) is highly expressed on activated endothelial cells and tumor neovasculature.
  • Inhibition of integrin alpha(v)beta(3) signaling demonstrates efficacy in preclinical models.
  • Integrin alpha(v)beta(3) antagonists show potential as targeted anti-cancer agents.

Conclusions:

  • Integrin alpha(v)beta(3) is a validated target for anti-angiogenic cancer therapy.
  • Various antagonists and targeted delivery systems are being developed for clinical application.
  • Further research into integrin alpha(v)beta(3) blockade holds promise for improved cancer treatment outcomes.

More Related Videos

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies06:27

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies

Published on: August 8, 2019

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...