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Related Experiment Video

Updated: Jun 11, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

[Systemic lupus erythematosus. A problem based approach].

S Kleinert¹, M Feuchtenberger, H-P Tony

¹Rheumatologie/Klinische Immunologie, Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg , Oberdürrbacher Strasse 6, 97080, Würzburg, Germany. Kleinert_S@klinik.uni-wuerzburg.de

|July 15, 2010

Summary

This summary is machine-generated.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Managing SLE involves accurate diagnosis, monitoring disease activity, and addressing comorbidities like infections and cardiovascular events to improve patient outcomes and reduce mortality.

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Last Updated: Jun 11, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice

Published on: November 1, 2015

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Area of Science:

Rheumatology
Immunology
Internal Medicine

Context:

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with variable clinical presentations.
Diagnosis requires clinical criteria and immunological markers, such as autoantibodies.
SLE management presents challenges due to its unpredictable course and potential for new symptoms.

Purpose:

This review discusses the diagnostic challenges and management strategies for Systemic Lupus Erythematosus.
It emphasizes a problem-based approach to understanding and addressing SLE symptoms.
The review highlights the importance of differentiating disease activity from associated complications.

Summary:

SLE diagnosis relies on clinical and immunological findings.
Disease activity monitoring is crucial for distinguishing flares from other issues like infections.
Key mortality factors in SLE patients include infections and cardiovascular events, necessitating comprehensive management.

Impact:

Effective SLE management requires timely immunosuppression and proactive treatment of comorbidities.
Controlling cardiovascular risk factors and managing osteoporosis are vital.
Early lifestyle modifications can improve long-term outcomes for individuals with SLE.