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A chemoenzymatic route to diversify aminoglycosides enables a microarray-based method to probe acetyltransferase

Pavel B Tsitovich1, Alexei Pushechnikov, Jonathan M French

  • 1Department of Chemistry & The Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, The State University of New York, 657 Natural Sciences Complex, Buffalo, NY 14260, USA.

Chembiochem : a European Journal of Chemical Biology
|July 15, 2010
PubMed
Summary

No abstract available in PubMed .

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...