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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

Published on: November 29, 2024

Targeted metabolomics for biomarker discovery.

William J Griffiths¹, Therese Koal, Yuqin Wang

¹Swansea University, School of Medicine, Institute of Mass Spectrometry, Singleton Park, Swansea SA2 8PP, UK.

Angewandte Chemie (International Ed. in English)

|July 15, 2010

Summary

Metabolomics uses advanced analytical chemistry and data analysis for biomarker discovery in diseases. This review highlights technical needs and recent developments for identifying and qualifying biomarkers using mass spectrometry.

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A Strategy for Sensitive, Large Scale Quantitative Metabolomics

A Strategy for Sensitive, Large Scale Quantitative Metabolomics

Published on: May 27, 2014

Area of Science:

Metabolomics
Analytical Chemistry
Systems Biology
Biomarker Discovery

Background:

Metabolomics integrates analytical chemistry, mass spectrometry, and NMR spectroscopy with data analysis.
It is crucial for biomarker discovery, encompassing pathobiochemistry, systems biology, and molecular diagnostics.
While established for neonatal screening, metabolomics is increasingly applied to diverse disease research.

Purpose of the Study:

To review technical prerequisites for metabolomics.
To highlight recent developments in metabolomics and data analysis.
To emphasize the utility in biomarker identification, qualification, and targeted metabolomics.

Main Methods:

High-throughput mass spectrometry
Nuclear Magnetic Resonance (NMR) spectroscopy
Bioinformatics and multivariate statistical analysis

Main Results:

Metabolomics is a powerful tool for biomarker identification and qualification.
Recent advancements enhance the application of metabolomics in disease diagnostics.
Targeted metabolomics using high-throughput mass spectrometry is a key development.

Conclusions:

Metabolomics is an interdisciplinary field essential for modern biomedical research.
Technical advancements are crucial for maximizing metabolomics' potential in biomarker discovery.
The review underscores the growing importance of metabolomics in disease characterization and diagnostics.