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Peripheral nervous system involvement in multiple sclerosis.

K Gartzen1, Z Katzarava, H-C Diener

  • 1Department of Neurology, University Clinic Essen, University of Duisburg-Essen, Essen, Germany. Kristina.Gartzen@uni-due.de

European Journal of Neurology
|July 16, 2010
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Summary

Standard nerve conduction velocity (SNC) tests revealed subtle peripheral nervous system (PNS) alterations in multiple sclerosis (MS) patients. However, pain-related evoked potentials (PREP) did not indicate small fibre neuropathy in this MS cohort.

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Area of Science:

  • Neuroscience
  • Neurology
  • Electrophysiology

Background:

  • Peripheral nervous system (PNS) affection in multiple sclerosis (MS) is subtle and often undetected by routine electrophysiological measurements.
  • Small fibre polyneuropathy, common in autoimmune diseases, has not been previously investigated in MS patients.

Purpose of the Study:

  • To investigate potential peripheral nervous system (PNS) involvement in multiple sclerosis (MS) patients.
  • To evaluate the utility of standard nerve conduction velocity (SNC) and pain-related evoked potentials (PREP) in detecting PNS affection in MS.

Main Methods:

  • Fifty-four MS patients underwent SNC of the tibial, sural, and peroneal nerves.
  • Twenty-one patients also underwent pain-related evoked potentials (PREP) testing.
  • The study included patients with relapsing-remitting and secondary progressive MS.

Main Results:

  • Subtle SNC abnormalities were detected in 29.6% of MS patients.
  • Abnormalities were found in 14.2% of all examined nerves.
  • No abnormalities were identified using pain-related evoked potentials (PREP).

Conclusions:

  • Routine electrophysiological measurements, specifically SNC, can reveal subtle PNS alterations in MS patients.
  • The study found no evidence of small fibre pathology in MS patients using PREP.
  • Further research may be needed to fully understand PNS involvement in MS.