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Appendicectomy and multiple sclerosis risk

H Roshanisefat1, S Bahmanyar, J Hillert

  • 1Department of Neurology, Karolinska University Hospital-Huddinge, Stockholm, Sweden. Homayoun.Roshanisefat@ki.se

European Journal of Neurology
|July 16, 2010
PubMed
Abstract

Insights

Appendectomy for acute appendicitis may be inversely associated with multiple sclerosis (MS) risk, but results were not statistically significant. This suggests diagnosis underlying appendectomy may influence MS risk.

Area of Science:

  • Neurology
  • Immunology
  • Epidemiology

Background:

  • Appendicectomy for acute appendicitis is linked to reduced risk of immune-mediated diseases.
  • This suggests appendicitis may indicate immune system characteristics influencing disease risk.
  • The association between appendectomy and multiple sclerosis (MS) risk requires further investigation.

Purpose of the Study:

  • To investigate the association between appendectomy and its underlying diagnosis with the risk of developing multiple sclerosis (MS).

Main Methods:

  • Utilized Swedish population registers and the Swedish MS register for data.
  • Included 20,542 MS cases and 204,157 matched controls.
  • Employed conditional logistic regression to assess the association between appendectomy diagnosis and MS risk.

Main Results:

  • A perforated appendix, indicating acute appendicitis, showed a non-significant inverse association with MS (OR 0.86).
  • Appendicitis without perforation had a slightly increased, non-significant odds ratio for MS (OR 1.04).
  • Appendectomy without appendicitis showed a non-significant increased odds ratio for MS (OR 1.14).

Conclusions:

  • The study's findings were inconclusive regarding the hypothesis on appendicitis and MS risk.
  • Variations in the diagnosis underlying appendectomy might explain inconsistencies in previous research on appendicitis and MS risk.

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