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Published on: July 26, 2024
Alpha-glucosidase inhibitory activity of bromophenol purified from the red alga Polyopes lancifolia
Keun Young Kim1, The Han Nguyen, Hideyuki Kurihara
1Dept. of Marine Food Science and Technology, Gangneung-Wonju Natl. Univ., Gangneung 210-702, Republic of Korea.
Abstract:
A bromophenol, bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, was purified from the red alga Polyopes lancifolia. Its IC(50) values were 0.098 and 0.120 microM against Saccharomyces cerevisiae and Bacillus stearothermophilus alpha-glucosidases, respectively, and 1.00 and 1.20 mM against rat-intestinal sucrase and maltase. This bromophenol competitively inhibited S. cerevisiae alpha-glucosidase with a K(I) value of 0.068 microM and was very stable at pH 2 for 60 min at 37 degrees C. Therefore, this P. lancifolia bromophenol may have potential as natural nutraceutical for the management of type 2 diabetes.
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