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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

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Related Experiment Video

Updated: Jun 10, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

True vasculitis in lupus nephritis.

A A Abdellatif1, S Waris, A Lakhani

  • 1Departments of Medicine, Baylor College of Medicine, The Methodist Hospital, Houston, TX 77030, USA. abdulla@bcm.edu

Clinical Nephrology
|July 16, 2010
PubMed
Summary
This summary is machine-generated.

True renal lupus vasculitis (TRLV) is a rare kidney vascular lesion in systemic lupus erythematosus (SLE) that requires distinct recognition. Understanding its unique features is crucial for accurate diagnosis and effective treatment of lupus nephritis.

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Last Updated: Jun 10, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Published on: June 8, 2022

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Area of Science:

  • Nephrology
  • Rheumatology
  • Pathology

Background:

  • Vascular lesions are common in lupus nephritis but true renal lupus vasculitis (TRLV) is under-recognized.
  • Focus on glomerular pathology often overshadows distinct vascular inflammatory conditions.

Purpose of the Study:

  • To comprehensively review the literature on TRLV in systemic lupus erythematosus (SLE).
  • To elucidate the epidemiology, morphology, pathogenesis, clinical course, and treatment of TRLV.
  • To differentiate TRLV from other renal vascular lesions in SLE.

Main Methods:

  • Comprehensive literature review of TRLV in SLE patients.
  • Morphological differentiation from other renal vascular pathologies.
  • Comparison with antineutrophil cytoplasmic autoantibody-associated vasculitis (AASV).

Main Results:

  • TRLV is morphologically distinct from arteriosclerosis, immune deposits, necrotizing vasculopathy, and thrombotic microangiopathy.
  • TRLV shares similarities with AASV but may involve pauci-immune pathogenesis.
  • TRLV typically presents with a severe clinical course and rapid renal failure, though some cases have favorable outcomes.

Conclusions:

  • TRLV is an under-recognized entity in lupus nephritis that warrants specific diagnostic consideration.
  • Further investigation into the pathogenesis, particularly potential pauci-immune mechanisms, is needed.
  • Treatment outcomes for TRLV are variable, necessitating exploration of targeted therapies beyond standard lupus nephritis or AASV protocols.