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Related Experiment Video

Updated: Jun 10, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Preclinical effectiveness of a novel pulp capping material.

Sabine H Dickens1, Glenn M Flaim, Gary E Schumacher

  • 1American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, MD 20899-8546, USA. sabine.dickens@nist.gov

Journal of Endodontics
|July 16, 2010
PubMed
Summary

A novel resin-based calcium phosphate cement (RCPC) demonstrated superior direct pulp capping outcomes. RCPC promoted significant dentin healing and repair in dog and ferret teeth compared to controls.

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Area of Science:

  • Dental Materials Science
  • Biomaterials Engineering
  • Regenerative Dentistry

Background:

  • Direct pulp capping is a clinical procedure to preserve pulp vitality.
  • Assessing new biomaterials for effective pulp repair is crucial.
  • Resin-based calcium phosphate cement (RCPC) is a novel material for dental applications.

Purpose of the Study:

  • To evaluate the direct pulp capping response to a novel resin-based calcium phosphate cement (RCPC).
  • To compare the efficacy of RCPC against a control material in promoting pulp healing and dentin repair.

Main Methods:

  • Direct pulp capping was performed on healthy dog pulps and healthy/inflamed ferret pulps.
  • Inflamed ferret pulps were induced with Salmonella typhimurium lipopolysaccharides.

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Accessing the Cytotoxicity and Cell Response to Biomaterials
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Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

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Last Updated: Jun 10, 2026

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice
07:07

Development of a Direct Pulp-capping Model for the Evaluation of Pulpal Wound Healing and Reparative Dentin Formation in Mice

Published on: January 12, 2017

Accessing the Cytotoxicity and Cell Response to Biomaterials
09:46

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

  • Teeth were treated with RCPC or visible light-curing resin-modified calcium hydroxide (VLCCH) and restored with composite resin.
  • Histological evaluation of pulp response and dentin repair was conducted at various time points.

    • Main Results:

    • RCPC treatment resulted in significant dentin healing and repair in most healthy dog pulps.
    • 75% of RCPC-treated inflamed ferret teeth showed evidence of dentin healing and repair.
    • Control teeth treated with VLCCH exhibited minimal healing and dentin repair.

    Conclusions:

    • Direct pulp capping with RCPC showed superior healing and repair capabilities.
    • RCPC is a promising material for direct pulp capping procedures.
    • The findings suggest RCPC enhances regenerative processes in dental pulp.