Related Experiment Video
Updated: Jun 10, 2026
08:50
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Renal hemodynamic changes with aging: a preliminary study using CT perfusion in the healthy elderly
Hong Zhao1, Jingshan Gong, Yan Wang
1Department of Radiology, The Fifth Affiliated Hospital of Zhongshan University, Zhuhai 519000, PR China.
Clinical Imaging
|July 16, 2010
Summary
Aging significantly alters renal blood flow (BF) and blood volume (BV), with time-to-peak (TTP) and mean transit time (MTT) increasing. CT perfusion imaging can assess these age-related renal hemodynamic changes in vivo.
Area of Science:
- Radiology
- Nephrology
- Gerontology
Background:
- Aging is associated with physiological changes in organ function.
- Renal hemodynamics are crucial for kidney health and function.
- Understanding age-related changes in renal perfusion is important for clinical management.
Purpose of the Study:
- To investigate changes in renal blood flow (BF) and blood volume (BV) parameters related to aging.
- To assess the correlation between aging and renal perfusion parameters using multislice spiral computed tomography (CT).
Main Methods:
- Prospective study involving 42 patients without obvious renal abnormalities.
- Renal perfusion scans performed using 16-slice spiral CT.
- Pearson correlation coefficient used to analyze the relationship between perfusion parameters and age.
Main Results:
- Blood flow (BF) and blood volume (BV) showed a negative correlation with age in both renal cortex and medulla.
- Time-to-peak (TTP) and mean transit time (MTT) demonstrated a positive correlation with age.
- BF, TTP, and MTT changes were statistically significant with age; BV correlation was not significant.
Conclusions:
- CT perfusion imaging is feasible for assessing in vivo renal hemodynamic changes associated with aging.
- Findings provide insights into age-related renal hemodynamics, aiding clinical work-up for elderly patients.
- Familiarity with these changes can assist in the management of aged patients.
Related Concept Videos
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
01:15Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...