Association between coronary spastic angina pectoris and obstructive sleep apnea
Akira Tamura1, Yoshiyuki Kawano, Shinichi Ando
1Internal Medicine 2, Faculty of Medicine, Oita University, Idaigaoka 1-1, Hasama-machi, Yufu 879-5593, Japan. akira@med.oita-u.ac.jp
Journal of Cardiology
|July 16, 2010
Summary
Obstructive sleep apnea (OSA) is more common in patients with coronary spastic angina pectoris (CSA). Moderate-to-severe OSA is independently linked to CSA, suggesting OSA may predispose individuals to coronary spasm.
Area of Science:
- Cardiology
- Sleep Medicine
- Pulmonology
Background:
- Obstructive sleep apnea (OSA) is prevalent in coronary artery disease patients.
- The link between OSA and coronary spastic angina pectoris (CSA) remains unexplored.
Purpose of the Study:
- To investigate the association between obstructive sleep apnea (OSA) and coronary spastic angina pectoris (CSA).
Main Methods:
- Overnight polysomnography was conducted on 42 CSA patients and 20 controls.
- OSA severity was categorized by apnea-hypopnea index (AHI): mild, moderate, and severe.
- Multivariate logistic regression analyzed the association between OSA and CSA.
Main Results:
- CSA patients exhibited a significantly higher AHI than controls (23.4±16.3 vs. 10.1±8.4, p=0.001).
- Moderate-to-severe OSA prevalence was higher in CSA patients (66.7%) compared to controls (20%, p=0.001).
- Moderate-to-severe OSA was an independent predictor of CSA (OR 9.61, p=0.003).
Conclusions:
- Moderate-to-severe OSA is significantly more prevalent in CSA patients.
- Moderate-to-severe OSA is an independent risk factor associated with CSA.
- OSA may be a predisposing factor for coronary spasm.
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