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An Optimized Protocol for the Efficient Radiolabeling of Gold Nanoparticles by Using a 125I-labeled Azide Prosthetic Group
Published on: October 10, 2016
A DOTA-peptide conjugate by copper-free click chemistry
Molly E Martin1, Sharavathi G Parameswarappa, M Sue O'Dorisio
1Department of Pediatrics, Carver College of Medicine, University of Iowa, 4235 MERF 375 Newton Road, Iowa City, IA 52242, USA.
Bioorganic & Medicinal Chemistry Letters
|July 16, 2010
Abstract:
Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.
