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Updated: Jun 10, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Serum 25-hydroxyvitamin D, parathyroid hormone, and mortality in older men
Peggy M Cawthon1, Neeta Parimi, Elizabeth Barrett-Connor
1California Pacific Medical Center Research Institute, California Pacific Medical Center, San Francisco, California 94107-1762, USA. pcawthon@sfcc-cpmc.net
Context:
Low 25-hydroxyvitamin D [25(OH)D] and high PTH may contribute to increased mortality risk in older adults.
Objective:
The aim of the study was to test the association between 25(OH)D, PTH, and mortality in older men.
Design And Setting:
The prospective Osteoporotic Fractures in Men (MrOS) study was conducted at six U.S. clinical centers.
Participants:
We studied community-dwelling men at least 65 yr old (n = 1490).
Main Outcome Measure:
Multivariate-adjusted proportional hazards models estimated the hazard ratio (HR) for mortality; cause of death was classified as cancer, cardiovascular, and other by central review of death certificates.
Results:
During 7.3 yr of follow-up, 330 (22.2%) participants died: 97 from cancer, 110 from cardiovascular disease, and 106 from other causes. The adjusted HR per sd decrease in 25(OH)D for all-cause mortality was 1.01 (95% CI, 0.89, 1.14); no association between 25(OH)D and cardiovascular or other-cause mortality was seen. Unexpectedly, lower 25(OH)D levels were modestly associated with a decreased risk of cancer mortality (adjusted HR per sd decrease, 0.80; 95% CI, 0.64, 0.99). Analyzing 25(OH)D as a categorical variable did not alter these results. Higher PTH levels (log-transformed) were associated with an increased risk of all-cause mortality (adjusted HR per sd increase, 1.15; 95% CI, 1.03, 1.29) and cardiovascular mortality (adjusted HR per sd increase in PTH, 1.21; 95% CI, 1.00, 1.45).
Conclusions:
In contrast to previous studies, lower 25(OH)D levels were not associated with an increased risk of all-cause or cause-specific mortality in older men. Higher PTH levels were associated with a modest increase in mortality risk.
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