Related Experiment Video

Updated: Jun 10, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance

Wendy Huang1, Christopher K Glass

  • 1Department of Cellular and Molecular Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|July 16, 2010
PubMed

Insights

Inflammation is a normal immune response, but prolonged inflammation causes tissue damage. Nuclear receptors offer potential therapeutic targets for chronic inflammatory diseases like atherosclerosis.

Area of Science:

  • Immunology
  • Molecular Biology
  • Pharmacology

Background:

  • Tissue inflammation is a critical immune process for host defense and repair.
  • Dysregulated or chronic inflammation leads to significant tissue damage and loss of function.
  • Nuclear receptors play a role in regulating inflammatory signaling pathways.

Purpose of the Study:

  • To review recent studies on signaling pathways in inflammatory response initiation.
  • To explore the role of nuclear receptors in counterregulating inflammation.
  • To identify potential pharmacological targets for chronic inflammatory diseases.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of transcriptional regulation in inflammation.
  • Investigation of nuclear receptor superfamily functions.

Main Results:

  • Signaling pathways at the transcriptional level initiate inflammatory responses.
  • Nuclear receptors modulate these inflammatory pathways.
  • Mechanisms of positive and negative transcriptional control are elucidated.

Conclusions:

  • Understanding nuclear receptor-inflammation interactions reveals key regulatory mechanisms.
  • These mechanisms offer novel therapeutic targets for chronic inflammatory conditions such as atherosclerosis.

More Related Videos

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...