Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of osteopathic manipulative medicine in cerebral palsy: bridging treatment gaps and enhancing care.

Journal of osteopathic medicine·2025
Same author

Hypoxia as a medicine.

Science translational medicine·2025
Same author

Battle of the sections: Student outcomes and course feedback support combined prosection and dissection laboratory formats to maximize student success.

Anatomical sciences education·2024
Same author

Circulating N-lactoyl-amino acids and N-formyl-methionine reflect mitochondrial dysfunction and predict mortality in septic shock.

Metabolomics : Official journal of the Metabolomic Society·2024
Same author

Student perceptions of remote versus on-campus gross anatomy laboratories during COVID-19.

Anatomical sciences education·2023
Same author

Hypoxia extends lifespan and neurological function in a mouse model of aging.

PLoS biology·2023

Related Experiment Video

Updated: Jun 10, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Bone loading during young adulthood predicts bone mineral density in physically active, middle-aged men.

Robert S Rogers1, Pamela S Hinton

  • 1, , Michael J. Langworthy MD 1 Amira Saad MD 2 Nadia M. Langworthy MD 3 1Battle Creek Orthopaedics and Sports Medicine Clinic Battle Creek MI 2Michigan State University East Lansing MI 3University of Michigan Ann Arbor MI Correspondence: Michael J. Langworthy MD Battle Creek Orthopaedics and Sports Medicine Clinic 6417 N. 39th St. Augusta MI 49012. Tel: 269-209-5066 Fax: 269-969-6283 E-mail: lcdrlang@aol.com, , .

The Physician and Sportsmedicine
|July 16, 2010
PubMed
Summary

Bone loading during young adulthood significantly predicts adult bone mineral density (BMD) in men. High-impact activities in both adolescence and young adulthood yield the greatest BMD benefits, supporting lifelong exercise for bone health.

More Related Videos

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Related Experiment Videos

Last Updated: Jun 10, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Cantilever Bending of Murine Femoral Necks
06:44

Cantilever Bending of Murine Femoral Necks

Published on: January 5, 2022

Area of Science:

  • Exercise physiology and bone health research.
  • Skeletal adaptations to physical activity.
  • Adult bone mineral density (BMD) assessment.

Background:

  • Physical activity during development enhances bone strength.
  • Long-term skeletal benefits of adolescent activity into middle age are not well understood.

Purpose of the Study:

  • To investigate the association between bone loading during adolescence and young adulthood and adult BMD in men.
  • To determine if high-impact activities during these periods have lasting positive effects on BMD.

Main Methods:

  • Cross-sectional study of 86 healthy, active men (aged 30-60 years).
  • Calculation of bone loading based on ground reaction forces (GRFs) from reported activities.
  • Assessment of BMD using dual-energy x-ray absorptiometry (DXA); regression analyses were performed.

Main Results:

  • Bone loading in young adulthood, not adolescence, significantly predicted adult BMD.
  • High-impact activity in both adolescence and young adulthood resulted in greater BMD than in adolescence only.
  • Body weight and lean mass, not bone loading, were linked to reduced risk of low bone density.

Conclusions:

  • Bone loading during young adulthood is crucial for maintaining adult bone mineral density.
  • Lifelong physical activity is recommended to preserve skeletal benefits from earlier life stages.
  • Participation in high-impact activities across adolescence and young adulthood maximizes bone health outcomes.