Related Experiment Video
Updated: Jun 10, 2026

Establishing a High Throughput Epidermal Spheroid Culture System to Model Keratinocyte Stem Cell Plasticity
Published on: January 30, 2021
Grabbing amphiregulin by the tail to better understand keratinocyte growth
1Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19101, USA. john.seykora@uphs.upenn.edu
Abstract:
Amphiregulin (AREG) is an important regulator of cellular growth in keratinocytes, carcinomas, and hyperproliferative epidermal disorders, including psoriasis. Stoll and colleagues present data suggesting that the cytoplasmic carboxy-terminal domain of amphiregulin plays an important role in regulating autocrine keratinocyte growth through the epidermal growth factor receptor. These observations raise novel and interesting biological questions regarding the function of the cytoplasmic C-terminal region of AREG.
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