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The IL-6 -174G/C polymorphism and renal scarring in children with first acute pyelonephritis

Brankica Spasojević-Dimitrijeva1, Maja Zivković, Aleksandra Stanković

  • 1Nephrology Department, University Children's Hospital, Belgrade, Serbia.

Pediatric Nephrology (Berlin, Germany)
|July 16, 2010
PubMed

Insights

Serum interleukin-6 (IL-6) is higher in children with acute pyelonephritis (APN) than lower urinary tract infections (UTI). However, IL-6 -174G/C gene polymorphism is not associated with APN or renal scarring in children.

Area of Science:

  • Pediatrics
  • Nephrology
  • Immunogenetics

Background:

  • Urinary tract infections (UTIs) are common in children and can lead to severe kidney complications like scarring and failure.
  • Identifying new markers for acute pyelonephritis (APN) is crucial for effective interventions to minimize kidney damage.

Purpose of the Study:

  • To investigate the relationship between interleukin-6 (IL-6) -174G/C polymorphism and renal scarring in children experiencing their first UTI.
  • To compare serum IL-6 levels and white blood cell (WBC) counts in children with APN versus lower UTIs.

Main Methods:

  • Prospective study of 71 children (1-24 months) with their first UTI.
  • Patients classified into APN and lower UTI groups using dimercaptosuccinic acid (DMSA) scans.
  • IL-6 -174G/C genotypes determined by tetra-primer ARMSPCR; serum IL-6 and WBC counts measured.

Main Results:

  • Serum IL-6 levels were significantly higher in the APN group compared to the lower UTI group (p<0.05).
  • The IL-6 -174G/C genotype and allele frequencies did not differ significantly between patient groups and controls.
  • The CC genotype was associated with the highest WBC count (p<0.05), with a non-significant trend towards higher serum IL-6.
  • Renal scarring was detected in 36.9% of APN children on follow-up DMSA scans.

Conclusions:

  • Serum IL-6 concentrations are significantly elevated in children with APN compared to those with lower UTIs.
  • IL-6 -174G/C polymorphism was not found to be significantly associated with APN or post-infectious renal scarring in this pediatric cohort.

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