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Dose correction strategy for the optimization of volumetric modulated arc therapy
Pengpeng Zhang1, Jie Yang, Margie Hunt
1Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. zhangp@mskcc.org
Medical Physics
|July 17, 2010
Summary
A new dose correction strategy for volumetric modulated arc therapy (VMAT) significantly reduces calculation discrepancies during treatment planning. This method improves plan quality and saves considerable time for radiation oncology planners.
Area of Science:
- Medical Physics
- Radiation Oncology
- Computational Biology
Background:
- Volumetric modulated arc therapy (VMAT) dose calculation during optimization uses approximations to manage computation time.
- These approximations in scatter dose calculation create discrepancies with more accurate post-optimization dose calculations.
Purpose of the Study:
- To develop and evaluate a dose correction strategy integrated into the VMAT optimization process.
- The goal is to minimize the disagreement between optimized and fully calculated doses.
Main Methods:
- A dose correction factor (C(ij)) was developed, calculated as the ratio of full scatter dose to partial scatter dose.
- These factors were applied during a multi-resolution VMAT optimization algorithm.
- The strategy was tested on clinical cases including brain, prostate, paraspinal, and esophagus.
Main Results:
- The dose difference between optimization and final calculation decreased from 7% and 5% to approximately 1% for PTV and OAR mean doses.
- Treatment planning time was reduced by an average of 2-4 hours.
- Plan quality improved, with higher PTV mean doses observed across all tested clinical sites.
Conclusions:
- Integrating dose correction into VMAT optimization effectively reduces dose discrepancies.
- This approach enhances planner confidence in adjusting optimization constraints.
- The strategy shows potential for improving overall VMAT treatment plan quality.
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