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Related Experiment Video

Updated: Jun 10, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

Human herpesvirus-6 entry into host cells.

Huamin Tang¹, Yasuko Mori

¹Laboratoy of Virology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8, Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

Future Microbiology

|July 17, 2010

Summary

Human herpesvirus-6B causes primary infections in children, while HHV-6A has no identified disease association. HHV-6 entry involves CD46 receptor and lipid rafts, suggesting a specific entry mechanism.

Area of Science:

Virology
Immunology

Background:

Human herpesvirus-6 (HHV-6) exists as two variants: HHV-6A and HHV-6B.
Primary HHV-6 infections and associated diseases in children are predominantly caused by HHV-6B.

Purpose of the Study:

To elucidate the cellular receptor and viral ligand involved in HHV-6 entry.
To investigate the role of lipid rafts in the HHV-6 cell entry mechanism.

Main Methods:

Identification of the cellular receptor for HHV-6.
Characterization of the viral ligand complex mediating entry.
Analysis of lipid raft involvement in the infection process.

Main Results:

The human CD46 molecule serves as the cellular receptor for HHV-6.

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The viral envelope glycoprotein complex gH/gL/gQ1/gQ2 is the ligand for HHV-6A.

Both cellular and viral lipid rafts are crucial for HHV-6 entry into target cells.

Conclusions:

HHV-6 utilizes the CD46 receptor for cellular entry.
The gH/gL/gQ1/gQ2 complex is implicated in HHV-6A binding.
HHV-6 infection likely employs a lipid raft-associated mechanism for cell entry.