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Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

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Related Experiment Video

Updated: Jun 10, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Commercialization challenges associated with induced pluripotent stem cell-based products.

¹Strategic Management Group, Pfizer Global R&D, 50 Pequot Avenue, MS6025-C4171, New London, CT 06320, USA. devyn.m.smith@pfizer.com

Regenerative Medicine

|July 17, 2010

Summary

This summary is machine-generated.

Induced pluripotent stem (iPS) cells offer non-therapeutic applications in drug discovery, generating revenue for future regenerative medicine advancements. Therapeutic applications face significant hurdles, with commercialization unlikely before the 2020s.

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Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

Derivation and Characterization of a Transgene-free Human Induced Pluripotent Stem Cell Line and Conversion into Defined Clinical-grade Conditions

Published on: November 26, 2014

Area of Science:

Regenerative Medicine
Stem Cell Biology
Biotechnology

Background:

Induced pluripotent stem (iPS) cells are a key innovation in regenerative medicine.
iPS cell-derived products are poised for near-term commercialization in non-therapeutic sectors.
Significant scientific and technical challenges impede the development of iPS cell-based therapies.

Purpose of the Study:

To analyze the commercialization landscape for iPS cell products.
To project the timeline for iPS cell-based therapeutic applications.
To highlight the importance of understanding business models for future iPS cell commercialization.

Main Methods:

Review of current market trends in regenerative medicine.
Analysis of scientific literature on iPS cell technology hurdles.
Evaluation of business models from existing cell-based therapies (autologous and allogeneic).

Main Results:

Non-therapeutic iPS cell products will launch within five years, providing crucial revenue and knowledge.
Commercialization of iPS cell-based therapies is projected for the 2020s due to technical and scientific challenges.
Established business models from other cell therapies are essential for future iPS cell commercialization.

Conclusions:

Near-term commercial opportunities lie in non-therapeutic iPS cell applications.
Overcoming scientific hurdles is critical for the eventual launch of iPS cell therapies.
Proactive development of robust business models, informed by existing cell therapy markets, is necessary for long-term success.