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Updated: Jun 10, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Double-bundle versus single-bundle ACL reconstruction.

Jason Boyer¹, Robert J Meislin

¹Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, NYU Langone Medical Center, New York, New York, USA.

Bulletin of the NYU Hospital for Joint Diseases

|July 17, 2010

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Double-bundle anterior cruciate ligament (ACL) reconstruction shows promise for improving knee injury outcomes. Further research and standardized techniques are needed to optimize ACL repair success rates.

Area of Science:

Orthopedic Surgery
Sports Medicine
Biomechanics

Background:

Anterior cruciate ligament (ACL) injuries are common, with surgical repair often yielding good results.
A significant percentage of patients (10-30%) experience persistent issues and fail to return to pre-injury activity levels after ACL repair.
Some athletes develop arthritis even after successful ligament reconstruction, indicating complex multifactorial causes.

Purpose of the Study:

To review the anatomical and historical basis of double-bundle ACL reconstruction.
To examine the biomechanics (kinematics) of double-bundle ACL reconstructions.
To compare clinical outcomes of double-bundle versus single-bundle ACL reconstruction techniques.

Main Methods:

Literature review of anatomical rationale for double-bundle ACL reconstruction.

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Last Updated: Jun 10, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Analysis of published kinematic studies on double-bundle techniques.

Comparative review of clinical outcomes from studies comparing double-bundle and single-bundle ACL reconstructions.

Main Results:

The review discusses the rationale and kinematics of double-bundle ACL reconstruction.
Clinical literature comparing double-bundle to single-bundle techniques is examined.
Outcomes suggest a need for further investigation into optimal surgical approaches.

Conclusions:

Standardization of outcome measurement parameters is crucial for ACL reconstruction research.
Advanced technologies may improve knee kinematic models for evaluating ACL reconstruction techniques.
Further research is needed to refine ACL reconstruction methods for better patient outcomes.