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Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

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Long-term motor cortex stimulation for amyotrophic lateral sclerosis.

Vincenzo Di Lazzaro¹, Michele Dileone, Fabio Pilato

¹Institute of Neurology, Università Cattolica, Largo A. Gemelli 8, Rome, Italy. vdilazzaro@rm.unicatt.it

Brain Stimulation

|July 17, 2010

Summary

Motor cortex stimulation may offer a slight benefit for amyotrophic lateral sclerosis (ALS) progression. One patient receiving repetitive transcranial magnetic stimulation (rTMS) showed reduced disease deterioration over two years.

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Published on: September 23, 2017

Area of Science:

Neurology
Neuroscience
Medical Technology

Background:

Motor cortex stimulation is a proposed treatment for amyotrophic lateral sclerosis (ALS).
Preliminary studies suggest potential benefits of invasive and noninvasive motor cortex stimulation in slowing ALS progression.

Purpose of the Study:

To investigate the long-term effects of motor cortex stimulation on ALS progression.
To evaluate the efficacy of prolonged motor cortex stimulation over approximately two years.

Main Methods:

A proof-of-principle study involving two ALS patients.
One patient received monthly repetitive transcranial magnetic stimulation (rTMS).
The second patient underwent chronic epidural motor cortex stimulation.

Main Results:

Both stimulation methods were well-tolerated.
Both patients experienced disease progression.
The patient treated with rTMS demonstrated a marginal decrease in the rate of deterioration.

Conclusions:

The observed effects in the rTMS patient warrant further investigation.
This study provides a foundation for future research on prolonged rTMS for ALS.
Larger clinical trials are needed to confirm the efficacy of rTMS in ALS treatment.