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Related Experiment Video

Updated: Jun 10, 2026

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation
10:27

A Standardized Protocol for Functional Motor Mapping Using Navigated Transcranial Magnetic Stimulation

Published on: February 27, 2026

Navigated transcranial magnetic stimulation does not decrease the variability of motor-evoked potentials.

Nikolai H Jung1, Igor Delvendahl, Nicola G Kuhnke

  • 1Department of Neuropaediatrics and Muscular Disorders, University Medical Center Freiburg, Germany.

Brain Stimulation
|July 17, 2010
PubMed
Summary
This summary is machine-generated.

Navigated transcranial magnetic stimulation (TMS) does not improve motor-evoked potential (MEP) amplitude variability or reproducibility. Neurophysiological factors, not coil positioning, likely cause MEP variability.

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Last Updated: Jun 10, 2026

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Area of Science:

  • Neuroscience
  • Neuromodulation

Background:

  • Transcranial magnetic stimulation (TMS) is known for motor-evoked potential (MEP) amplitude variability, potentially due to coil positioning.
  • Navigated TMS (nTMS) offers high accuracy (2.5 mm) and stable coil positioning.

Purpose of the Study:

  • To determine if nTMS enhances spatial constancy, thereby reducing MEP amplitude variability and improving inter-session reproducibility.

Main Methods:

  • Eight healthy subjects underwent TMS with and without an optically tracked frameless navigational device.
  • Input-output curves, motor thresholds, and MEP amplitudes were recorded.
  • Coefficient of variation calculated for MEP amplitude variability; inter-session reproducibility assessed.

Main Results:

  • No significant difference in MEP amplitude variability (coefficient of variation) between navigated and non-navigated TMS.
  • MEP amplitudes showed no significant difference in reproducibility between sessions with and without nTMS.

Conclusions:

  • The study does not support the hypothesis that nTMS improves MEP amplitude variability or reproducibility.
  • MEP variability may be primarily influenced by non-controllable neurophysiological factors like cortical excitability and spinal desynchronization.