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Updated: Jun 10, 2026
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
Published on: October 24, 2017
Are second-trimester minor sonographic markers for Down syndrome useful in patients who have undergone
Monica Sood1, Burton Rochelson, David Krantz
1Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA. msood@nshs.edu
Objective:
We sought to determine efficacy of minor markers for detection of Down syndrome (DS) in a population prescreened with first-trimester combined screening (FTS).
Study Design:
FTS was modified using established likelihood ratios to generate a new composite risk (NCR).
Results:
Of 3845 women, 390 had ≥1 marker. There were 10/3845 cases of DS; 3 were among patients with low-risk FTS (n = 3727). In 55 patients, NCR adjusted the risk from low to high without increasing detection rate. NCR did not modify risk to allow for detection of the 3 DS among patients with low-risk FTS even though 2 of these fetuses had 1 minor marker each. There were 7 DS among patients with high-risk FTS (n = 118). Use of NCR increased positive predictive value from 7/118 (5.1%) to 7/53 (13.2%).
Conclusion:
Screening for minor markers is useful in patients with high-risk FTS. It is of questionable benefit in patients with low-risk FTS.
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