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Dual inhibition of wound healing and oxidative process by montelukast in experimental colon anastomoses
Emel Canbay1, Bedia Agachan, Tulin Ozturk
1General Surgery, Basaksehir State Hospital, Basaksehir, Istanbul, Turkey. dremelcanbay@gmail.com
Background:
The authors aimed to investigate the effects of montelukast (ML) on the experimental rat colon anastomosis.
Methods:
A total of 80 Wistar albino rats were divided into 4 groups: sham-operated, colon anastomosis, and colon anastomosis with oral administration (OAML) and rectal administration of 10 mg/kg/d ML (RAML). Anastomotic bursting pressure, anastomotic hydroxyproline contents, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPX), and superoxide dismutase (SOD) levels, and the expressions of Ki-67, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) with immunohistochemistry were assessed on postoperative day 5.
Results:
Anastomotic bursting pressures and bFGF expressions were not changed, whereas tissue hydroxyproline concentrations and MDA levels and the expressions of Ki-67 and VEGF were significantly decreased, and GSH, GPX, and SOD levels were significantly increased in the OAML and RAML groups.
Conclusion:
ML causes impairment of wound healing without altering the anastomosis bursting pressure and reverses the oxidative damage of the colon anastomoses in rats.
