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Updated: Jun 10, 2026

Surgical Porcine Model of Chronic Myocardial Ischemia Treated by Exosome-laden Collagen Patch and Off-pump Coronary Artery Bypass Graft
Published on: September 15, 2023
Transmyocardial laser revascularization 12 years later
Stefano Pratali1, Francesca Chiaramonti, Aldo Milano
1Section of Cardiac Surgery, Cardiac Thoracic and Vascular Department, University of Pisa Medical School, Pisa, Italy.
Abstract:
We report the long-term follow-up of 34 patients who underwent transmyocardial laser revascularization (TMLR) from 1995 to 1999. At 12 years the actuarial survival is 24%±8%, actuarial freedom from cardiac deaths is 36%±10% and actuarial freedom from major adverse cardiac events 13%±8%. Mean angina class of nine current survivors is 2.7±0.6. Based on these results, the use of TMLR as an isolated procedure remains questionable. TMLR could probably achieve better results when employed in combination with myocardial revascularization or as a vehicle of intramyocardial growth factors.
