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Mutational effects and the evolution of new protein functions

Misha Soskine1, Dan S Tawfik

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

Nature Reviews. Genetics
|July 17, 2010
PubMed

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Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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