Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strain-Tunable Thermal Conductivity in Largely Amorphous Polyolefin Fibers via Alignment-Induced Vibrational Delocalization.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

An Elastocaloric Polymer with Ultra-High Solid-State Cooling via Defect Engineering.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

High-efficiency atmospheric water harvesting enabled by ultrasonic extraction.

Nature communications·2025
Same author

Nonreciprocal reflection of mid-infrared light by highly doped InAs at low magnetic fields.

Optics express·2025
Same author

Nonreciprocal Hyperbolic and Surface Modes Enable Tunable Near-Field Heat Transfer in Current-Biased Dirac Semimetals.

Nano letters·2025
Same author

Inverse design and optical vortex manipulation for thin-film absorption enhancement.

Nanophotonics (Berlin, Germany)·2024

Related Experiment Video

Updated: Jun 10, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Self-referenced photonic molecule bio(chemical)sensor.

Svetlana V Boriskina1, Luca Dal Negro

  • 1Department of Electrical and Computer Engineering & Photonics Center, Boston University, Boston, Massachusetts 02215, USA. sboriskina@gmail.com

Optics Letters
|July 17, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a novel optical biosensor that distinguishes between surface and bulk changes. It accurately detects specific molecular binding and measures adsorbed layer thickness using coupled microcavities.

More Related Videos

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Label-free Single Molecule Detection Using Microtoroid Optical Resonators
08:53

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Related Experiment Videos

Last Updated: Jun 10, 2026

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors
10:59

Use of Label-free Optical Biosensors to Detect Modulation of Potassium Channels by G-protein Coupled Receptors

Published on: February 10, 2014

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents
09:35

Attaching Biological Probes to Silica Optical Biosensors Using Silane Coupling Agents

Published on: May 1, 2012

Label-free Single Molecule Detection Using Microtoroid Optical Resonators
08:53

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Area of Science:

  • Optics
  • Biophysics
  • Materials Science

Background:

  • Optical biosensors are crucial for molecular detection.
  • Distinguishing between surface and bulk refractive index changes remains a challenge.
  • Identifying specific molecular binding in complex samples requires high sensitivity.

Purpose of the Study:

  • To develop a new optical biosensor.
  • To differentiate between bulk and surface refractive index perturbations.
  • To distinguish specific from nonspecific molecular binding.
  • To estimate the thickness of adsorbed molecular layers.

Main Methods:

  • Utilizing coupled optical microcavities (photonic molecules).
  • Tracking spectral shifts of hybridized bonding and antibonding optical modes.
  • Employing two spectral shift measurements for discrimination.

Main Results:

  • Successfully differentiated between surface and bulk refractive index changes.
  • Demonstrated detection of specific target molecules in complex environments.
  • Enabled estimation of thin adsorbed layer thicknesses.
  • Showcased the sensor's capability to distinguish specific from nonspecific binding.

Conclusions:

  • The proposed photonic molecule-based biosensor offers advanced capabilities for molecular analysis.
  • This method provides a robust way to differentiate various perturbation types.
  • The sensor shows promise for sensitive and specific biomolecular detection and surface characterization.