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Circulating endothelial microparticles in diabetes mellitus

A F Tramontano1, R Lyubarova, J Tsiakos

  • 1Division of Cardiology, Fletcher Allen Health Care and the University of Vermont School of Medicine, Burlington, VT 05401, USA. antoniotramontano@hotmail.com

Mediators of Inflammation
|July 17, 2010
PubMed
Abstract

Insights

Elevated endothelial microparticles (EMPs) with specific markers were found in diabetes mellitus (DM) patients. These EMPs, reflecting cell death, may aid in assessing diabetes risk.

Area of Science:

  • Cardiovascular Research
  • Endothelial Biology
  • Diabetes Mellitus Research

Background:

  • Endothelial microparticles (EMPs) are vesicles from activated or apoptotic endothelial cells, mediating cell communication.
  • The variation in EMP immunophenotypes based on stimuli in Diabetes Mellitus (DM) is not well understood.
  • This study investigated the cellular adhesion molecule (CAM) profile of circulating EMPs in patients with and without type 2 DM undergoing cardiac catheterization.

Purpose of the Study:

  • To determine if EMP immunophenotypes differ in patients with Diabetes Mellitus.
  • To assess the association between specific EMP markers and DM.
  • To explore the potential of EMPs as predictors of DM and indicators of apoptotic processes.

Main Methods:

  • Circulating EMPs were isolated from patients with and without type 2 DM.
  • Flow cytometry was used to analyze EMPs for specific markers, including CD31, CD105, and CD106.
  • The ratio of CD62E/CD31 EMP populations was examined to infer apoptotic processes.

Main Results:

  • The absolute median number of CD31+, CD105+, and CD106+ EMPs was significantly higher in the DM group.
  • EMPs were identified as the sole independent predictors of DM within the study cohort.
  • The immunophenotype of EMPs indicated an ongoing apoptotic process.

Conclusions:

  • Circulating EMPs expressing CD31, CD105, and CD106 are significantly elevated in individuals with DM.
  • EMPs emerged as independent predictors of Diabetes Mellitus.
  • The EMP immunophenotype provides insights into apoptotic processes and suggests potential for risk assessment in DM.

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