Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus
Related Experiment Video
Updated: Jun 10, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
Published on: January 12, 2024
Inge A M van den Oever1, Hennie G Raterman, Mike T Nurmohamed
1Department of Rheumatology, Jan van Breemen Institute, Amsterdam, The Netherlands.
Abstract:
Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabetes related complications. This review summarizes the mechanisms by which the interplay between endothelial dysfunction, inflammation, and apoptosis may cause (micro)vascular damage in patients with diabetes mellitus.
Related Concept Videos
Diabetic Retinopathy
Diabetic Nephropathy
Type II Diabetes II: Pathophysiology
Type I Diabetes II: Pathophysiology
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Diabetic Neuropathy