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Updated: Jun 10, 2026
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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Cortical lesions and cognitive impairment in multiple sclerosis
F Rinaldi1, M Calabrese, P Grossi
1Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, University Hospital of Padova, Padua, Italy. francyrinaldi@yahoo.com
Summary
Multiple sclerosis involves grey matter lesions, particularly in the cerebral cortex. These cortical lesions (CL) correlate with physical disability and cognitive impairment in patients.
Area of Science:
- Neurology
- Neuroimaging
- Neuroinflammation
Background:
- Multiple sclerosis (MS) is a chronic central nervous system disease.
- Grey matter lesions, especially in the cerebral cortex, are increasingly recognized in MS.
- Cortical lesions (CL) contribute to neurological deficits.
Purpose of the Study:
- To investigate the role of cortical lesions (CL) in multiple sclerosis.
- To correlate CL burden with clinical outcomes in MS patients.
Main Methods:
- Utilized double inversion recovery (DIR) magnetic resonance imaging (MRI) to detect CL in vivo.
- Correlated CL findings with measures of physical disability and cognitive impairment.
Main Results:
- Cortical inflammatory lesions (CL) are detectable using DIR MRI in MS patients.
- CL burden is associated with the severity of physical disability.
- CL are a significant factor in disease-related cognitive impairment.
Conclusions:
- Cortical lesions are a key pathological feature in multiple sclerosis.
- DIR MRI is effective in visualizing CL and assessing their impact.
- CL burden is a crucial biomarker for both physical and cognitive decline in MS.
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