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Immunity induced in rats vaccinated with toxoid prepared from heat-labile toxin produced by Pasteurella multocida
J R Thurston1, R B Rimler, M R Ackermann
1United States Department of Agriculture, Agricultural Research Service, Ames, IA 50010.
Veterinary Microbiology
|April 1, 1991
Abstract:
Rats were vaccinated with a toxoid (D-toxoid) prepared from purified heat-labile toxin (D-toxin) produced by Pasteurella multocida serogroup D. Vaccination of rats with D-toxoid prevented death and other effects of D-toxin (hepatic necrosis, development of elevated leukocyte counts, lymphopenia, neutrophilia, and elevated complement titers) that occurred in phosphate buffered saline (PBS)-vaccinated control rats.