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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...

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A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation
16:40

A New Single Chamber Implantable Defibrillator with Atrial Sensing: A Practical Demonstration of Sensing and Ease of Implantation

Published on: February 28, 2012

Subcutaneous ICD implantation.

Pedro Jerónimo Sousa1, Diogo Cavaco, José Pedro Neves

  • 1Servigo de Cardiologia, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, Portugal. p965675551@gmail.com

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|July 20, 2010
PubMed
Summary
This summary is machine-generated.

A patient with hypertrophic cardiomyopathy experienced inappropriate shocks due to implantable cardioverter defibrillator lead fracture. A new subcutaneous defibrillator was successfully implanted, offering a lower risk of complications like lead fracture or infection.

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy presents risks requiring defibrillator implantation.
  • Implantable cardioverter defibrillators (ICDs) can be associated with lead complications such as fracture.
  • Lead fractures can lead to inappropriate shocks and device malfunction.

Observation:

  • An 18-year-old patient with hypertrophic cardiomyopathy and a 6-year-old ICD experienced inappropriate shocks due to lead fracture.
  • The malfunctioning ICD lead (Sprint Quattro, Medtronic) necessitated device explantation.
  • A novel subcutaneous cardioverter defibrillator (Cameron SQ-RX) was implanted without complications.

Findings:

  • The subcutaneous cardioverter defibrillator implantation was technically successful.
  • This marked the first use of a subcutaneous cardioverter defibrillator in the Iberian Peninsula.
  • The subcutaneous device demonstrated good rhythm diagnostic performance and therapeutic efficacy.

Implications:

  • Subcutaneous implantable defibrillators may reduce risks of lead fracture and infection compared to transvenous systems.
  • This case highlights the potential of subcutaneous defibrillators as a viable alternative for patients with hypertrophic cardiomyopathy.
  • Further research into subcutaneous defibrillator technology is warranted for improved patient outcomes.