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Updated: Jun 10, 2026

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Primary oral malignant melanoma: case report.

Tatjana Bujas¹, Ivana Pavić, Andrej Prus

¹Department of Pathology and Forensic Medicine, Karlovac General Hospital, Karlovac, Croatia.

Acta Clinica Croatica

|July 20, 2010

Summary

Primary oral malignant melanoma is a rare cancer with a poor prognosis. Treatment involves surgery, potentially with radiation, chemotherapy, or immunotherapy.

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

Oncology
Oral Pathology
Dermatology

Background:

Primary oral malignant melanoma is a rare cancer, comprising less than 1% of all melanomas.
It accounts for 1.6% of head and neck malignancies and 0.5% of oral malignancies globally.
Oral melanoma generally has a poorer prognosis compared to cutaneous melanoma.

Observation:

Presents as a dark brown or black lesion in the oral cavity.
A specific case involved a rapidly growing mass noticed six months prior to biopsy.
This highlights the aggressive nature some oral melanomas can exhibit.

Findings:

Oral malignant melanoma is characterized by its rarity and poor prognosis.
Standard treatment involves radical surgery, often combined with adjuvant therapies.
Adjuvant therapies may include radiotherapy, chemotherapy, immunotherapy, and immunomodulatory agents.

Implications:

Early detection and diagnosis are crucial for improving patient outcomes.
Multimodal treatment strategies are essential for managing this aggressive malignancy.
Further research into targeted therapies may enhance the prognosis for oral melanoma patients.