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Is the Behcet's disease a risk factor for osteoporosis and is relation to cytokines?

M Kirnap1, M Calis, N Kaya

  • 1Department of Physical Medicine and Rehabilitation, Erciyes University Medical School, Kayseri, Turkey.

Bratislavske Lekarske Listy
|July 20, 2010
PubMed

Insights

Behcet's disease may increase osteoporosis risk, particularly in the lumbar spine. Higher bone-specific alkaline phosphatase and TNF-alpha levels were observed in patients, suggesting altered bone metabolism.

Area of Science:

  • Rheumatology
  • Endocrinology
  • Bone Metabolism

Background:

  • Behcet's disease is a chronic inflammatory disorder affecting multiple systems.
  • The potential impact of Behcet's disease on bone mineral density (BMD) is not fully understood.

Purpose of the Study:

  • To investigate the relationship between Behcet's disease and bone mineral density.
  • To explore the association between cytokines and bone metabolism markers in Behcet's disease patients.

Main Methods:

  • Compared BMD, bone formation markers (osteocalcin, BALP), bone resorption marker (DOP), and cytokine levels (IL-1, TNF-alpha) in 60 Behcet's disease patients and 24 healthy controls.
  • Utilized dual-energy X-ray absorptiometry (DEXA) for BMD measurements at the lumbar spine and femur.

Main Results:

  • Significantly higher BALP levels and TNF-alpha levels were found in Behcet's disease patients compared to controls.
  • Lumbar spine BMD was significantly lower in Behcet's disease patients.
  • No significant differences in osteocalcin or urine deoxypyridinolin levels were observed.

Conclusions:

  • Behcet's disease is a potential risk factor for osteoporosis, especially affecting the lumbar spine.
  • A negative correlation was identified between IL-1 levels and femur neck BMD.
Abstract

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