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Updated: Jun 10, 2026

Experimental Analysis of Apoptotic Thymocyte Engulfment by Macrophages
Published on: May 24, 2019
The role of ascorbic acid and monosodium glutamate in thymocyte apoptosis
1Institute of Physiology, Medical Faculty University of Nis, Serbia. vojapav@yahoo.com
Abstract:
The studies on experimental animals have confirmed toxic effect of monosodium glutamate in different organs, mainly manifested by increased oxidative stress and cytotoxicity, strongly correlated with numerous diseases. Continuous intake of this flavor enhancer in modern nutrition also resulted with toxic effects on human health, known as Chinese restaurant syndrome. The reference data about influence of monosodium glutamate on the cells of the immune system or primary immune organs and possible protective effects of specific antioxidants are still largely unknown. This review summarizes recently known facts about the role of monosodium glutamate in the cells of the immune system, especially in thymocytes. Also, in this review many new data on positive effects of ascorbic acid on immune system and the mechanisms of its protective influence on thymocytes are discussed (Tab. 1, Ref. 52).
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