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[The side effects of korinfar in hypertension patients]
Vrachebnoe Delo
|April 1, 1991
Insights
Corinfar treatment for hypertension can cause cerebrovascular side effects due to increased blood flow to the brain. Cerebral hemodynamics, specifically artery distensibility and vascular resistance, help predict these effects.
Area of Science:
- Neurology
- Cardiology
- Pharmacology
Background:
- Hypertensive disease poses significant risks for cerebrovascular complications.
- Corinfar (nifedipine) is a calcium channel blocker used to manage hypertension.
- Cerebrovascular side effects have been observed during corinfar treatment.
Purpose of the Study:
- To investigate the link between corinfar treatment and cerebrovascular side effects in hypertensive patients.
- To identify hemodynamic parameters that can predict the occurrence of these side effects.
Main Methods:
- Patients with hypertensive disease undergoing corinfar treatment were monitored.
- Cerebral hemodynamics were examined, focusing on pulse arterial inflow into the cranial cavity.
- Measurements included cerebral artery distensibility and peripheral vascular resistance.
Main Results:
- A significant increase in pulse arterial inflow into the cranial cavity was associated with cerebrovascular side effects.
- Cerebral artery distensibility and peripheral vascular resistance values correlated with the development of side effects.
Conclusions:
- The development of cerebrovascular side effects during corinfar treatment is linked to increased cranial arterial blood flow.
- Assessing cerebral hemodynamics, particularly artery distensibility and vascular resistance, can aid in predicting these adverse events.
Abstract:
It was established that the appearance of cerebrovascular side-effects due to corinfar treatment in patients with hypertensive disease is related to a significant increase of the pulse arterial inflow into the cranial cavity. Examination of the cerebral hemodynamics allows to realize their prognosis by the values of distensibility of the cerebral arteries and peripheral vascular resistance.