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Related Experiment Video

Updated: Jun 10, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Noonan syndrome: A case report.

G Ierardo¹, V Luzzi, F Panetta

¹Sapienza University of Rome, Italy, Department of Paediatric Dentistry.

European Journal of Paediatric Dentistry

|July 20, 2010

Summary

This summary is machine-generated.

Noonan syndrome, a genetic disorder on chromosome 12, presents with various systemic issues. Early orthodontic intervention with functional appliances can address dental and facial asymmetry in affected children.

Related Experiment Videos

Last Updated: Jun 10, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Area of Science:

Genetics
Pediatrics
Orthodontics

Background:

Noonan syndrome is a rare genetic disorder caused by alterations in genes, with the primary gene located on chromosome 12.
This condition can manifest with a range of systemic complications affecting multiple organ systems.

Observation:

A case study involved an eight-year-old Caucasian girl diagnosed with Noonan syndrome.
The patient presented with otitis, cardiac issues, speech difficulties, lower limb asymmetry, and mild cognitive delay.
A notable habit of lower lip sucking was also observed.

Findings:

The diagnostic evaluation confirmed Noonan syndrome.
The patient exhibited characteristic systemic and developmental features associated with the condition.

Implications:

This case highlights the importance of early diagnosis and multidisciplinary management for Noonan syndrome.
Orthodontic treatment, including tooth extraction, molar sealing, and functional appliance use, was initiated to manage dental and facial irregularities.
Addressing such issues can potentially improve quality of life for individuals with Noonan syndrome.