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Plasma urocortin in acute myocardial infarction patients

Arintaya Phrommintikul1, Sivaporn Sivasinprasasn, Narissara Lailerd

  • 1Cardiac Electrophysiology Research and Training Center, Cardiology Division, Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand.

European Journal of Clinical Investigation
|July 20, 2010
PubMed

Insights

Plasma urocortin levels are elevated in acute myocardial infarction (AMI) patients for five days. High early plasma urocortin predicts increased mortality, and combining it with NT-proBNP improves prognostic accuracy.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • The cardioprotective role of urocortin is proposed but its function in acute myocardial infarction (AMI) is unclear.
  • Investigating plasma urocortin levels and their prognostic value in AMI patients is crucial.

Purpose of the Study:

  • To determine the plasma profile of urocortin in AMI patients.
  • To evaluate the long-term prognostic performance of plasma urocortin in AMI.

Main Methods:

  • Sixty-six AMI patients and 21 healthy controls were enrolled.
  • Plasma urocortin levels were measured on days 0, 1, 3, 5, and at 3 and 6 months post-onset.
  • Primary endpoint was 1-year mortality; secondary endpoint was a composite of death and adverse cardiac events.

Main Results:

  • Plasma urocortin was elevated in AMI patients for up to 5 days.
  • Day 0 urocortin showed an AUC of 0.750 for mortality prediction (P=0.004).
  • Combining urocortin and NT-proBNP demonstrated superior prognostic performance for mortality and adverse events.

Conclusions:

  • Elevated plasma urocortin is observed in AMI patients for 5 days post-onset.
  • High plasma urocortin within 24 hours of onset is linked to increased mortality.
  • Combined urocortin and NT-proBNP levels enhance prognostic accuracy in AMI.
Abstract

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