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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

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Related Experiment Video

Updated: Jun 10, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Current progress in ABO-incompatible liver transplantation.

Minoru Tanabe1, Shigeyuki Kawachi, Hideaki Obara

  • 1Department of Surgery, Keio University School of Medicine, Tokyo, Japan. m-tanabe@sc.itc.keio.ac.jp

European Journal of Clinical Investigation
|July 20, 2010
PubMed
Summary
This summary is machine-generated.

Advances in liver transplantation have improved outcomes for ABO-incompatible (ABOi) living donor liver transplantation (LDLT). Treatment breakthroughs, including local graft infusion and rituximab, have made ABOi LDLT results comparable to ABO-compatible procedures in Japan.

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Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
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Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

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Last Updated: Jun 10, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt
12:27

Technique of Porcine Liver Procurement and Orthotopic Transplantation using an Active Porto-Caval Shunt

Published on: May 7, 2015

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Immunology

Background:

  • ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has faced challenges due to antibody-mediated rejection (AMR).
  • Preformed anti-ABO antibodies pose a significant risk in ABOi LDLT.
  • Recent treatment advancements have led to improved outcomes in ABOi LDLT.

Purpose of the Study:

  • To review the history and progress of ABOi liver transplantation.
  • To highlight the Japanese experience and key treatment developments.
  • To discuss strategies for overcoming the ABO blood group barrier in LDLT.

Main Methods:

  • Review of historical data and current practices in ABOi liver transplantation.
  • Focus on Japanese contributions and therapeutic innovations.
  • Analysis of treatment strategies including local graft infusion and rituximab prophylaxis.

Main Results:

  • Early ABOi LDLT outcomes were poor, particularly in adults.
  • Portal vein infusion therapy and local graft infusion emerged as critical breakthroughs.
  • Rituximab prophylaxis combined with local graft infusion significantly improved patient survival.
  • Intravenous immunoglobulin induction shows promise for AMR suppression.

Conclusions:

  • Outcomes of ABOi LDLT in Japan now rival those of blood-type-matched transplantation.
  • Infection remains the primary cause of morbidity and mortality post-ABOi LDLT.
  • Future directions involve evaluating immune status and optimizing immunosuppression.