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Related Experiment Video

Updated: Jun 10, 2026

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy

Published on: March 29, 2020

Decrease of Trefoil factor 2 in cats with feline idiopathic cystitis.

Stephanie I K Lemberger¹, Roswitha Dorsch, Stefanie M Hauck

¹Clinic of Small Animal Medicine, Department of Veterinary Sciences, LMU University of Munich, Germany.

BJU International

|July 20, 2010

Summary

This summary is machine-generated.

Feline idiopathic cystitis (FIC) in cats is linked to a deficiency in Trefoil factor 2 (TFF2), a protein crucial for bladder healing. This discovery may lead to new diagnostic biomarkers for FIC and offers insights into human interstitial cystitis.

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Published on: February 11, 2017

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Last Updated: Jun 10, 2026

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy

Identification of Neutrophil Extracellular Traps in Paraffin-Embedded Feline Arterial Thrombi using Immunofluorescence Microscopy

Published on: March 29, 2020

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Forskolin-induced Swelling in Intestinal Organoids: An In Vitro Assay for Assessing Drug Response in Cystic Fibrosis Patients

Published on: February 11, 2017

Area of Science:

Veterinary Medicine
Urology
Biochemistry

Background:

Feline idiopathic cystitis (FIC) is a common, poorly understood condition in cats.
Identifying etiological factors and diagnostic biomarkers for FIC is crucial for improving feline health.
Urinary protein profiles may offer insights into the pathogenesis of FIC.

Purpose of the Study:

To investigate differences in urinary proteins between cats with FIC and healthy controls.
To identify potential diagnostic biomarkers for FIC.
To explore the role of specific proteins, like Trefoil factor 2 (TFF2), in FIC.

Main Methods:

Comparative analysis of urinary protein profiles using two-dimensional (2-D) gel electrophoresis.
Identification of differentially expressed proteins via tandem mass spectrometry.
Validation of Trefoil factor 2 (TFF2) expression using Western blot and immunohistochemistry.

Main Results:

Eleven differentially expressed protein spots were identified between FIC and control cats.
Albumin was upregulated in FIC cats, while Trefoil factor 2 (TFF2) was significantly decreased.
Reduced TFF2 expression in FIC cats was confirmed through Western blot and immunohistochemistry.

Conclusions:

TFF2 deficiency may impair urothelial repair and immune response, contributing to FIC pathogenesis.
Decreased urinary TFF2 shows potential as a diagnostic biomarker for FIC.
Findings may be relevant to human interstitial cystitis research, given FIC's role as an animal model.