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Related Experiment Videos

Postnatal changes in lymphocyte function of dairy calves.

H Nagahata1, N Kojima, I Higashitani

  • 1Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.

Zentralblatt Fur Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B
|February 1, 1991
PubMed
Summary

Neonatal calf lymphocytes show low antibody production in the first month of life. B-lymphocyte populations increase, but overall immune function, including antibody production, remains underdeveloped during this critical early period.

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Area of Science:

  • Immunology
  • Veterinary Medicine
  • Neonatal Calf Health

Background:

  • Neonatal calves have immature immune systems.
  • Understanding lymphocyte function is crucial for assessing early-life immunity in calves.

Purpose of the Study:

  • To evaluate lymphocyte function in neonatal calves during the first four weeks of life.
  • To assess B-lymphocyte population, blastogenic response, and antibody-producing activity.

Main Methods:

  • Determined B-lymphocyte percentage and absolute counts.
  • Measured lymphocyte blastogenic response using Con A, PHA, and PWM.
  • Quantified antibody-producing cells (plaque-forming cells) via cultured lymphocytes.

Main Results:

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  • B-lymphocyte percentage increased from 10.2-12.5% (0-14 days) to 15.3-17.5% (21-28 days).
  • Absolute B-lymphocyte count significantly increased from birth to 28 days.
  • Antibody-producing activity was significantly lower in calves within the first three weeks compared to those older than three weeks.

    • Conclusions:

    • Neonatal calf lymphocytes exhibit low antibody-producing activity for at least the first month after birth.
    • While B-lymphocyte numbers increase, their functional capacity for antibody production is limited in early life.