Current status of stem cell mobilization

Area of Science:

• Hematology
• Oncology
• Stem Cell Transplantation

Background:

• Advances in stem cell mobilization have increased patient eligibility for autologous stem cell transplantation.
• Peripheral blood stem cells (PBSCs) are increasingly utilized, necessitating a review of mobilization strategies.

Purpose of the Study:

• To review the relative merits of peripheral blood versus bone marrow stem cell sources.
• To critically assess available mobilization agents, including growth factors and chemotherapy combinations.
• To provide recommendations for patients with poor stem cell mobilization, including the use of plerixafor.

Main Methods:

• Literature review of current practices and available agents for stem cell mobilization.
• Critical assessment of growth factor dosing and frequency.
• Analysis of common chemotherapy plus growth factor regimens.
• Evaluation of strategies for poor mobilizers.

Main Results:

• Peripheral blood stem cell mobilization has improved transplant accessibility.
• Various agents and combinations exist, each with specific efficacy and dosing considerations.
• Plerixafor offers a solution for patients who are poor mobilizers.

Conclusions:

• Optimized mobilization strategies enhance the success of autologous stem cell transplantation.
• Understanding agent efficacy and appropriate use is crucial for patient selection.
• Plerixafor represents a significant advancement for challenging mobilization cases.