Related Experiment Video
Updated: Jun 10, 2026
08:49
Cultivating a Three-dimensional Reconstructed Human Epidermis at a Large Scale
Published on: May 28, 2021
Recent advances in skin 'barrier' research.
1AVR Consulting Ltd, Northwich, Cheshire, UK. TonyRawlings@aol.com
The Journal of Pharmacy and Pharmacology
|July 20, 2010
Summary
The stratum corneum
Area of Science:
- Dermatology and skin biology.
- Skin barrier function and structure.
Background:
- Stratum corneum (SC) biology, chemistry, and biophysics knowledge has advanced significantly.
- Understanding SC structural maturity and its control mechanisms is crucial.
Purpose of the Study:
- To review the growing knowledge of stratum corneum complexity.
- To discuss intricate control mechanisms governing SC structural maturity and desquamation.
Main Methods:
- Literature review of recent advancements in SC research.
- Synthesis of current understanding of SC architecture, barrier function, and desquamation.
Main Results:
- The SC's overall architecture is vital for desquamation and barrier function.
- Corneodesmosomes, their enzymes, natural moisturizing factor (NMF), and the antimicrobial barrier are key components.
- New insights into NMF and the SC's chemical antimicrobial barrier are emerging.
Conclusions:
- Despite advances, a complete understanding of SC maturity and desquamation control mechanisms remains elusive.
- Further research is needed to fully elucidate the complex regulatory pathways.
More Related Videos
Related Concept Videos
01:18Surface Membrane Barriers
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
01:12Renewal of Skin Epidermal Stem Cells
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
01:27The Skin Microbiota
The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...